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成人碘摄入量与甲状腺功能关系的研究

ISSN号：0253-9896
期刊名称：天津医药
时间：0
页码：164-166
分类：R581.104[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
作者机构：[1]天津医科大学公共卫生学院营养教研室,300070, [2]天津医科大学总医院特检中心, [3]天津医科大学内分泌研究所, [4]天津医科大学公共卫生学院卫化教研室
相关基金：国家自然科学基金重点资助项目（项目编号：30230330）; 国营养学会基金资助项目（项目编号：2004091）; 国家自然科学基金资助项目（项目编号：30571564）
相关项目：碘摄入过量致甲状腺功能减退的现况调查及发病机制的研究

作者：桑仲娜|董作亮|刘嘉玉|沈均|吴蕴棠|陈祖培|张万起|SANG Zhongna, DONG Zuoliang, LIU Jiayu, SHEN Jun,|

关键词：碘, 甲状腺功能试验, 甲状腺激素类, 成年人, 随机对照试验, iodine thyroid function tests thyroid hormones adult randomized controlled trial

中文摘要：

目的：观察不同碘摄入水平甲状腺功能正常的健康成人对甲状腺功能的影响。方法：选择甲状腺功能正常的健康志愿者161例,随机分为7组,各组每人每天分别服用500μg,750μg,1000μg,1250μg,1500μg,1750μg,2000μg的碘补充剂,为期4周。采用化学发光法测定血清FT3、FT4、sTSH浓度。结果：与补碘前相比,补碘后各组受试者血清FT3在正常值范围内呈下降趋势,除1250μg和1750μg剂量组外其余各组差异有统计学意义（P〈0.05或P〈0.01）;补碘后血清FT4呈轻度下降趋势,至1500μg剂量组时,在正常值范围内明显下降（P〈0.05或P〈0.01）;各组人群在补充碘剂2周后（500μg和750μg组在4周后）血清sTSH明显上升（P〈0.05或P〈0.01）。各剂量组间血清FT3、FT4和sTSH相比差异无统计学意义（均P〉0.05）。结论：碘营养充足的人群短期高剂量碘摄入时表现为血清sTSH水平增高。

英文摘要：

Objective： To observe the effect of different iodine intake on the thyroid function in euthyroid adult persons. Methods： One hundred and sixty-one euthyroid healthy volunteers aged 18-24 years were randomly divided into 7 groups. Each group was assigned to receive 500 μg, 750 μg, 1 000 μg, 1 250 μg, 1 500 μg, and 2 000 μg iodide/day for four weeks. Serum concentrations of free triiodothyronine（FT3）, free thyroxin（FT4） and sensitive thyroid-stimulating hormone （sTSH） were measured by chemoluminescence assays. Results： Serum FT3 concentration was found a small decline within the normal range in all the iodide supplemented groups （P 0.05）. The level of FT4 was significantly lower, when the dose was up to 1 500 μg （P 0.05）. The level of serum sTSH was increased after 2 weeks iodide supplement in all groups, and after 4 weeks in 500 μg and 750 μg groups（P 0.05）. No significant changes were observed in FT3,FT4 and sTSH between groups（P 0.05）. Conclu- sion： The thyroid function of normal people showed a rise in serum sTSH at a short time and a high-dose of iodine intake.

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