中文摘要：

目的探讨不同碘水平对实验性自身免疫甲状腺炎（experimental autoimmune thyroiditis,EAT）大鼠抗氧化活性的影响。方法选择雌性Lewis大鼠,随机分为4组;于实验第8周处死动物,观察大鼠甲状腺组织的病理变化,测定甲状腺球蛋白抗体（TGAb）、甲状组甲状腺腺微粒体抗体（TMAb）,肝和脑组织中谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）活性。结果各造模组织出现淋巴细胞浸润,高碘时以甲状腺滤泡扩张、融合为主,低碘时以增生为主;高碘＋造模组大鼠的TGAb和TMAb水平分别为（75.00±15.44）%,（72.15±15.00）%,明显高于造模组的（63.01±12.36）%,（60.62±11.24）%和低碘＋造模组的（58.87±9.57）%,（57.89±9.67）%（P〈0.05）;低碘组EAT大鼠肝组织GSH-Px和SOD活性最低,分别为（122.01±10.34）,（522.81±54.62）U/（mg.prot）（P〈0.05）碘过量时脑组织谷胱甘肽过氧化物酶（GPX）活性最低,为（412.09±115.71）U/（mg.prot）（P〈0.05）。结论碘缺乏和碘过量均能够加重EAT大鼠甲状腺的炎性损伤和氧化损伤,其中碘缺乏对EAT大鼠作用明显。

英文摘要：

Objective To explore the effects of different levels of iodine on activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） in EAT rats’liver and brain.Methods Female Lewis rats were chosen to make EAT model with pig thyroglobulin and divided into 4 groups randomly（control,model,model and excess iodine,and model and low iodine group）.The pathological changes of thyroid gland tissue were observed and thyroglobulin antibody（TGAb）,thyroid microsomal antibody（TMAb）,activities of SOD and GSH-Px in rats’liver and brain were detected 8 weeks after the treatment.Results The lymphocytes infiltration was observed under light microscope in model and low iodine group.Some of thyroid folials were destroyed in model and excess iodine group.The main changes in rats iodine excess groups were expanding and confluence in thyroid follicle.The proliferation was the main change in rats of iodine deficiency group.Compared with that of model group,the levels of TGAb （75.00±15.44%）and TMAb（72.15±15.00%）in rats of model and low iodine group were significantly higher（P0.05）.The activities of GSH-Px（122.01±10.34 mg·prot）and SOD（522.81±54.62 mg·prot）of rats’liver in model and low iodine group were lower than that of other groups （P0.05）.The activity of brain GSH-Px（412.09±115.71 mg·prot）was the lowest in model and excess iodine group（P0.05）.Conclusion Iodine deficiency and iodine excess in EAT rats may led to progress of the disease,and the effect of iodine deficiency seems more serious.