中文摘要：

研究了3,5-二甲基苯基异氰酸酯对羟丙基-β-环糊精固定相的手性识别影响.通过异氰酸丙基三乙氧基硅烷作偶联剂,将羟丙基-β-环糊精键合到3-氨丙基硅烷化硅胶上,再用3,5-二甲基苯基异氰酸酯对β-环糊精和硅胶其余羟基进行衍生化,制得一种新型的3,5-二甲基苯基氨基甲酸酯全衍生化羟丙基-β-环糊精键合硅胶手性固定相.在反相色谱条件下,对9种手性药物进行了拆分,结果表明,3,5-二甲基苯基氨基全衍生化固定相较之羟丙基-β-环糊精固定相有更好的分离效果.

英文摘要：

The effect of 3,5 -dimethylphenyl isocyanate on the chiral recognition of hydroxypropyl-β-cyclodextfin bonded stationary phase has been studied. Hydroxypropyl hydroxypropyl-β- cyclodextrin; chiral stationary phase; chiral separation Classifying cyclodextrin, bonded to 3 - aminopropyhfiethoxysilane through （3 - isocyanatopropyl ） triethoxysilane was used as the coupling agent, then other hydroxyl groups of -β- CD and silica gel were derivatized with 3,5 - dimethylphenyl isocyanate, thus a 3,5 - dimethylphenylcarbamate perderivatized hydroxypropyl --β- cyclodextrin bonded silica gel stationary phase was prepared. The chiral resolution of nine chiral drugs in reversed phase chromatography showed that 3,5 - dimethylphenylcarbamate perderivatized hydroxypropy1-β-cyclodextrin bonded stationary phase has better separation result than that of hydroxypropyl-β-eyclodextrin bonded stationary phase.