中文摘要：

鉴于其无创实时及较高的确诊率,超声造影成像在癌症诊断中扮演着愈发重要的角色。其中,如何提高造影信号强度、持续时间与图像质量,是工程界最为关注的要点。因此,全面总结近年来国内外在超声造影成像工程技术领域的最新进展,主要包括4个方面：一是基于弱衰减性低频回波检测,进而具有更高信噪比和造影-组织比率的新型非线性成像方法——次谐波造影成像;二是能够提升图像时间分辨率以及降低微泡击碎程度/延长持续时间的平面波造影技术;三是旨在提升造影图像穿透力的编码发射技术;四是针对超高频造影应用场合的新型造影剂研究。

英文摘要：

Due to its characteristics of noninvasive,real-time,and high diagnosis ratios,contrast-enhanced ultrasound imaging has played an increasingly important role in cancer diagnosis. Herein,the latest research progress of contrast-enhanced ultrasound imaging was summarized in this paper,mainly including following aspects： 1） Subharmonic ultrasound imaging with a higher contrast-to-tissue ratio and superior penetration performance,which are due to detection of the lower frequency component of the microbubbles’ backscatter echoes; 2） Application of plane-wave emission technology in ultrasound contrast imaging that is capable of increasing temporal resolution whilst reducing microbubble’s destruction; 3） Coded excitation based ultrasound contrast imaging to obtain a better penetration; 4） Experimental research on new types of ultrasound contrast agents for ultrahigh frequency imaging.