用路易斯碱二甲基甲酰胺(DMF)催化三氯氢硅(HSiCl3)还原烯胺合成对应的胺,最佳反应条件为:烯胺0.1mmol,DMF0.5eq.,HSiCl3 4.0eq.,DCM 1mL,于0℃反应12h,胺的收率在93%以上。
Enamines were reduced to corresponding amines by trichlorosilane (HSiCl3 ) using Lewis base dimethylformamide(DMF) as a catalyst. The yields of amines were over 93% under the optimal reaction conditions with enamine 0.1 mmol, DMF 0.5 eq. , HSiCl3 4.0 eq. and DCM 1 mL at 0 ℃ for 12 h.