中文摘要：

对采自湛江红树林内生真菌Nigrosporasp．的次级代谢产物进行了首次研究。利用硅胶柱层析、制备薄层层析和重结晶等方法，从该菌培养液的乙酸乙酯相中分离得到3个聚酮类次级代谢产物，运用现代波谱技术鉴定其结构分别为Griseofulvin（1），Vermixocin B（2）和Tenellic acid A（1）。化合物1的立体结构还通过X射线单晶衍射进一步得以确定。体外细胞毒活性测试表明，化合物1对人口腔表皮样癌（鳞癌）细胞KB，人口腔鳞癌多药耐药细胞KBV200，和人肺腺癌细胞A549的细胞毒活性IC50分别为8．23，9．10和14．26μmol／L。

英文摘要：

Research on the secondary metabolites of the mangrove endophytic fungus Nigrospora sp. from the South China Sea was reported. Three secondary metabolites were isolated from the ethyl acetate ex- tract of the fermentation by silica gel column chromatography, preparative thin layer chromatography and recrystallgraphy. Their structures were identified by comprehensive spectroscopic methods as Griseofulvin （1） , Vermixocin B （2） , Tenellic acid A （3）. The absolute configuration of compound 1 was further confirmed by single-crystal X-ray analysis. The cytotoxic activity of compound 1 in vitro was also evalua- ted, and compound 1 showed medium activity against KB, KBV200, and A549 cell lines with IC50 of 8.23, 9. 10 and 14. 26 p~mol/L, respectively.