中文摘要：

为了提高血管支架的力学性能,将生物相容性良好的新型生物材料类人胶原蛋白（基因工程技术、高密度发酵生产）与丝素蛋白以质量比9：1、7：3、5：5复合,采用真空冷冻方法制备管状血管支架。研究了不同配比血管支架材料的表面结构、表面元素组成、力学性能、降解和生物相容性。结果表明：当类人胶原蛋白与丝素蛋白的质量比为7：3混合时,类人胶原蛋白-丝素蛋白管状支架具有均匀的多孔结构,孔径为（60±5）μm,孔隙率达到85%以上;获得了较理想的力学性能：应变为50%±5%,应力为（332±16）kPa;具有相对慢的降解速率;提高了细胞的黏附与增殖,具有良好的生物相容性。

英文摘要：

In order to improve tensile property of vascular scaffold,we blended silk fibroin with novel human-like collagen with the mass ratio of 9：1,7：3 and 5：5（W/W）,and then fabricated blood vessel tubular graft by freeze-drying process.We studied microstructure,mechanical properties,elements composites,degradability and biocompatibility of vascular scaffolds.These results showed that tubular scaffold with mass ratio 7：3 exhibited interconnected porous structure with pore size at（60 ± 5） μm and porosity of 85%; achieved the desirable mechanical property （strain of 50%±5% and stress of 332±16 kPa）; had relatively slow degradation rate; could enhance cell adhesion and proliferation and had superior biocompatibility.