中文摘要：

口腔亚健康是指口腔处于健康与疾病状态之间的一种状态,其灵敏辨别与准确检测对于维护儿童和成人群体的身心健康均具重大意义。最新研究表明,口腔共生菌群的特异性结构或功能变化可先于口腔临床症状出现,因此具备预测疾病发生的潜力。首先,综述了口腔菌群与口腔内生态位、宿主年龄、疾病状态等的关联,讨论了基于口腔菌群定义与检测牙齿、牙周组织的亚健康状态的现有证据及潜力;其次,以微生物组大数据和单细胞分析为例,探讨了新一代微生物组分析技术的最新进展和应用前景。基于微生物组的口腔亚健康状态检测与机制研究,将为口腔乃至全身的精准医疗与精准护理提供新思路和新工具。

英文摘要：

The state of ＂sub-optimal health＂（So H）, an intermediate phase between the healthy state and the diseased state, is of crucial importance for promoting the wellbeing of both child and adult populations. Recent findings revealed that specific structural and functional alteration of oral microbiota can precede the emergence of clinical symptoms in oral cavity, suggesting oral microbiota can be employed for predicting disease onsets. Here we reviewed the correlation of oral microbiota with oral ecological niche, host development and type and state of oral infections, and discussed current evidence as well as the potential of defining and detecting So H of both teeth and gum tissues via microbiota. Furthermore, we introduced the recent development of new-generation microbiota analysis technologies, using big-data platform and single-cell analysis as examples. Further studies that detect and dissect So H based on oral microbiota will lead to new ways of thinking and novel solutions for precision medicine and personalized care of both oral ecosystem and whole human body.