中文摘要：

根据相关研究及国外有关文献资料,对斑马鱼药物代谢的实验方法、代谢类型及适用性进行归纳和总结。斑马鱼较成功地模拟了哺乳动物Ⅰ相代谢、Ⅱ相代谢、肠道菌群代谢及多途径整体代谢,适用于微量单体化合物及其组合物的在体代谢研究,有利于代谢产物的简单、高效富集,具简单、高效、低成本、化合物用量少（毫克级）等优势,是一种早期、快速预测微量成分在体代谢的极具前景的模式生物模型。

英文摘要：

According to relative research and foreign references,we summarized the experimental method,drug metabolism type,and applicability of drug metabolism model in zebrafish.Zebrafish successfully simulated the mammals in phase I metabolism,phase II metabolism,intestinal bacteria metabolism,and multiway in vivo metabolism.Zebrafish is suitable for in vivo metabolism of trace monomeric compounds and their combinations,and is benefit for the efficient enrichment of metabolites in simple way.It has the advantages of simplity,high efficiency,low cost,and less amount of compound（a few mg） etc.It is a very prospect organisms model for early and rapid prediction of in vivo metabolism of trace elements.