中文摘要：

目的 研究维持性血透（maintenanceheamodialysis，MHD）患者血清N末端B型钠尿肽原（NT—probrainnatriureticpeptide，NT—proBNP）水平与干体重的关系，寻找有效的评价干体重的方法。方法分别测定18例干体重控制良好（干体重达标组）MHD患者和20例干体重控制不良MHD患者（干体重未达标组）血清NT—proBNP，测定干体重未达标组患者经过4周下调干体重治疗前后的血清NT—proBNP的水平，记录各患者临床、生化数据及心功能阶段分级fACC／AHA）。结果所有MHD患者血清NT—proBNP水平高于临床诊断值3419．3（2368．7—5728．3）pg／ml。干体重达标组的血清NT—proBNP水平2872．4（1907．3～3655．9）pg／ml，干体重未达标组的血清NT—proBNP水平4568．4（3236．3～6530．4）pg／ml，两组数据比较有统计学意义（P〈0．01）；干体重未达标组治疗前后血清NT—proBNP水平中位数（4568．4vs2569．Opg／m1）明显下降，有统计学意义（P〈0．01）。结论血清NT—oroBNP水平能反映MHD的干体重，可作为干体重评估的简单、有效方法。

英文摘要：

Objective To investigate the relationship between plasma NT-pro brain natriuretic peptide （NT-proBNP） levels and dry weight in patients in maintenance hemodialysis （MHD） and to evaluate the clinical value of NT-proBNP in the assessment of dry weight. Methods NT-proBNP level was determined in 18 cases of MHD patients with well-controlled dry weight and 20 cases of MHD patients with bad-controlled dry weight, while the latter would be checked once again after the weight was down-regulated to dry weight in 4 weeks. Results The average level of NT-proBNP was 3419.3（2368.7-5728.3 ） pg/ml which was higher than normal. Plasma NT-proBNP levels were significantly lower in patients with well-controlled dry weight than those patients with bad-controlled dry weight （2872.4 vs 4568.4） pg/ml, and there was very significant difference in plasma NT-proBNP levels between pre and post treatment of down-regulation to dry weight in patients with bad-controlled dry weight （4568.4 vs 2569.0） pg/ml. Conclusions Plasma NT-proBNP can be a good marker for the evaluation of dry weight in MHD patients.