中文摘要：

嘌呤受体分为腺苷作用的P1受体和ATP作用的P2受体两大类;P2受体又分为P2X（离子通道受体）和P2Y（G蛋白耦联受体）。多种嘌呤受体亚型表达于内分泌胰腺,并参与调节胰岛素的分泌。嘌呤受体和配体与糖尿病及其并发症的发病机制密切相关,并可能成为糖尿病及其并发症治疗的新靶点。

英文摘要：

Purinergic receptors are divided into P1 （adenosine） and P2 （ATP） receptors. P2 receptor are divided into two subtypes,namely P2X （ligand-gated ion channels） and P2Y （G- protein coupled） receptors. Several kinds of purinoceptor subtypes have been expressed in endocrine pancreas and participate in regulating the secretion of insulin. Purinoceptor and ligand are correlated with pathogenesis of diabetes mellitus and complications and make it possible to provide a new target to treat diabetes mellitus and complications.