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中文摘要：
ATP（adenosine 5’-triphophate）是一种嘌呤类物质,参与神经传递和神经调节。随着嘌呤、嘧啶受体亚家族研究的深入,ATP及其受体可能是多种疾病防治的潜在药物靶点。体外研究应用共振能量转移技术,指数级富集的配体系统进化技术及在体小干扰RNA技术可拓宽嘌呤信号转导研究的视野,也将推动其在疾病防治及药物筛选方面的研究进展。
英文摘要：
ATP（adenosine 5′-triphophate）is a kind of purine involved in neural transmission and regulation.With the in-depth studying about purine and pyrimidine receptor subfamilies,ATP and its receptor will become a variety of potential drug targets of disease control.The application of resonance energy transfer technology,systematic evolution of ligands by exponential enrichment in vitro and small interfering RNA technology in vivo not only expand the perspective of purinergic signaling research,but also promote their progress in disease prevention and drug screening.
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