欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
细胞外的嘌呤（腺苷、一磷酸腺苷、二磷酸腺苷、三磷酸腺苷）和嘧啶是重要的信号分子,通过作用于细胞表面特定的嘌呤和嘧啶受体,发挥着它们的作用。细胞外核苷酸类P2嘌呤受体是比较复杂的受体家族之一,主要以两种形式存在：配体门控离子通道型（P2X）和G蛋白偶联代谢型（P2Y）。P2X受体与细胞信号转导之间的关系相对简单,而P2Y受体则较为复杂。本文就P2嘌呤受体介导和调节细胞内信号转导的机制进行综述。
英文摘要：
Purine（adenosine,adenosine monophosphate,adenosine diphosphate,triphosadenine） and pyrimidine are important signaling molecules that play their role through specified purine and pyrimidine receptors on cell surface.P2 purine receptors for extracellular nucleotides belong to one of the complex receptor families,which are divided into two categories： the ligand-gated ion channel receptors（P2X） and the G-protein-coupled metabolic receptors（P2Y）.For P2X receptors,signal transduction appears to be relatively simple,while for P2Y receptors,signal transduction is more complex.These intracellular signaling pathways and their regulation by P2 purine receptors are discussed in this review.
同期刊论文项目
同项目期刊论文
Effects of oxymatrine on sympathoexcitatory reflex induced by myocardial ischemic signaling mediated
P2X receptors and modulation of pain transmission: Focus on effects of drugs and compounds used in t
Sensory-sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitat
Intrathecal leptin inhibits expression of the P2X2/3 receptors and alleviates neuropathic pain induc
Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial isch
VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X(2/3) receptor of p
Effects of anti-rVEGF on the expression of VEGF receptor-2 and P2X2/3 receptors of the spinal dorsal
Vatalanib decrease the positive interaction of VEGF receptor-2 and P2X2/3 receptor in chronic constr
位置：