中文摘要：

筛选1株具有高效降胆固醇活性的乳酸菌菌株并研究其降胆固醇的特性。采用分离自新疆酸马奶的10株乳酸菌,通过益生活性的测定以及降胆固醇实验筛选得到1株具有高效降胆固醇的益生菌株SM-7,经过鉴定为发酵乳杆菌。该菌株在液体培养基中的胆固醇脱除率为66.82%,用该菌液饲喂小鼠4周,研究其对小鼠血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）以及体质量和肝、肾质量的影响。结果显示,实验组小鼠的血清TC、TG、LDL-C含量均显著低于高脂模型组（P〈0.01）,而HDL-C含量没有显著差异（P〉0.05）。这表明发酵乳杆菌SM-7对实验性高脂血症小鼠血清有显著的降胆固醇作用。

英文摘要：

The strain SM-7 with hpocholesterolemic activity was screened from 10 lactic acid bacteria（LAB） strains isolated from koumiss in Xinjiang and its hpocholesterolemic effect in mice was investigated.The SM-7 was identified as Lactobacillus fermentum and could reduce 66.82% of cholesterol in the medium.The effect of strain SM-7 on serum TC,TG,HDL-C,LDLC,body weight,liver and kidney were investigated in ICR mice with hyperlipemia.Results showed serum TC,TG and LDL-C concentrations were exhibited a significant decrease（P 0.01） while no obvious change was observed in serum HDL-C concentration（P 0.05）.These investigations suggested that Lactobacillus fermentum SM-7 strain had a significant effect on cholesterol-reducing function in mice with hyperlipemia.