中文摘要：

目的：研究小建中汤及其拆方对芍药苷含量的影响。方法：采用Diamonsil RP-C18色谱柱（250 mm×4.6 mm,5μm）,以乙腈-水为流动相,流速1.0 mL·min-1,检测波长230 nm。结果：小建中汤拆方前后芍药苷的含量有明显变化,其中去甘草组、去桂枝组、去饴糖组与全方组比较均有显著性差异（P〈0.05）;去生姜组、去大枣组与全方组比较无显著性差异（P〉0.05）。结论：甘草和桂枝有助于白芍中芍药苷的溶出;大枣、生姜对白芍中芍药苷的溶出影响不大;饴糖可能会以小团块形式包裹芍药苷,使实验中芍药苷的萃取效率降低。

英文摘要：

This study was aimed to investigate the effect of Xiao-Jian-Zhong decoction and its disassembled prescriptions on the content determination of paeoniflorin . A gradient HPLC system was used in the quantitative analysis of paeoniflorin on Diamonsil RP-C18 column （ 250 mm × 4 . 6 mm , 5 μm ） with the mixed solvents of acetonitrile and water . The flow rate was 1 . 0 mL？min-1 and the detection wavelength was 230 nm . The results showed that the content of paeoniflorin had great changes comparing with X iao-Jian-Zhong decoction with its different disassembled prescriptions . The analysis of variance showed that the difference among groups was sig-nificant （P 〈 0.05）. SNKq analysis showed that there was significant difference between groups 6 and 1, 6 and 2 , 6 and 5 （ P 〈 0 . 05 ） . But no significant difference was existed among group 6 , 3 and 4 （ P 〉 0 . 05 ） . It was concluded that liquorice and cassia twigs were helpful to the dissolution of paeoniflorin in the decoction . But jujube and ginger had few effects . The content of paeoniflorin in group 5 which does not include maltose was the highest among all groups . It may be due to the fact that paeoniflorin was wrapped in the maltose of X iao-Jian-Zhong decoction .