中文摘要：

目的：探讨外周血中淋巴细胞与单核细胞比值（LMR）对原发性肝癌（PLC）根治性切除术后预后的预测价值。方法：收集接受肝癌根治性切除术且术前未接受其他治疗的PLC患者447例的临床及实验室资料,根据术前外周血检查结果计算LMR,绘制术前LMR诊断患者术后5 a生存状态的ROC曲线,确定LMR诊断界值。采用Kaplan-Meier法和COX回归模型分析PLC患者术后5 a生存的影响因素。结果：术前LMR诊断界值为3.03,据此将LMR分为高（≥3.03）和低（〈3.03）两种状态。COX分析结果显示术前高LMR是PLC患者术后预后的保护因素（β=-0.329,HR=0.720,95%CI=0.562-0.921）。结论：术前LMR可用于评价PLC根治性切除术后患者的预后,术前高LMR患者预后较好。

英文摘要：

Aim： To investigate the prognostic value of lymphocyte-to-monocyte ratio（ LMR） in primary liver cancer（ PLC） patients after curative hepatectomy. Methods： Clinical and laboratory data of 447 PLC patients who were treated by curative hepatectomy were collected. None of the patients received any other treatments before surgery. LMR was calculated. The optimal cutoff was determined by receiver operating characteristics（ ROC） curve analysis. Kaplan-Meier survival analysis and COX proportional hazard model were used to evaluate the influence of LMR on patients＇ overall survival. Results： The optimal cutoff value of LMR for survival analysis was 3. 03,and all the patients were accordingly allocated into high LMR（ ≥3. 03） group and low LMR（ 3. 03） group. The COX univariate and multivariate analysis showed that enhanced LMR was an independent favorable prognostic factor for overall survival（ β =- 0. 329,HR = 0. 720; 95% CI =0. 562- 0. 921）. Conclusion： LMR is an independent prognostic factor for PLC patients underwent curative hepatectomy,and patients with high LMR indicate favorable overall survival.