中文摘要：

目的探讨肿瘤坏死因子-α（TNF-α）、内毒素（LPS）、白细胞介素-6（IL-6）在重症颅脑损伤急性肝功能损害发生过程中的相关因素。方法收集2011年6月—2013年6月在急诊科就诊,创伤指数（TI）≥17分、格拉斯哥昏迷评分（GCS）≤10分,除外合并其它部位损伤及在急诊死亡的重症颅脑损伤患者65例,急诊救治的同时抽血检查谷丙转氨酶（ALT）、谷草转氨酶（AST）、TNF-α、LPS、IL-6,与正常对照组相比较,并对观察组病例的检验结果进行相关性分析。结果观察组肝功能检验结果：ALT：279.43±41.35（U/L）,AST：258.49±39.62（U/L）;损伤因子检验结果：TNF-α：39.93±18.88（ng/ml）,LPS：479.38±91.48（IU/L）,IL-6：469.61±73.66（ng/ml）。与对照组同类数据相比,P均〈0.001,均有显著的统计学意义,有明显的差别。观察组ALT与TNF-α、LPS、IL-6比较,其相关系数（r）均大于0.8552,AST与TNF-α、LPS、IL-6比较r均大于0.8574,均有显著的统计学意义,均呈显著正相关。结论 TNF-α、LPS、IL-6参与了重症颅脑损伤急性肝功能损害的发生、发展。在急诊救治重症颅脑损伤时,早期的加强对TNF-α、LPS、IL-6的干预,则有可能减轻急性肝功能损害的程度。

英文摘要：

Objective To investigate the correlation between tumor necrosis factor-α（ TNF-α）,lipopolysaccharide（LPS）、interleukin-6（IL-6）with acute liver factional lesion on severe craniocerebral injury. Methods Totally 65 subjects with severe craniocerebral injury are collected in the 253 th Hospital of PLA from January in 2009 to June in 2012,of whom the trauma index are all above or equal to 17 points,glasgow coma scale low or equal to 10 points. They are examined alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,TNF-α,LPS,IL-6 for correlative analysis while they are emergency treated at the same time. Results Injury factors xamined results：TNF-α：（39. 93 ± 18. 88）ng /ml,LPS：（479. 38 ± 91. 48）IU /L,IL-6（469. 61 ± 73. 66）ng /ml. It both has evidently difference between the control group and observe group and has obviously correlation between the liver function and injury factors of observe group.Conclusion TNF-α,LPS and IL-6 all participate in the process of the acute liver functional lesion in severe craniocerebral injury. The inchoate interference and treatment in TNF-α,LPS,IL-6 is possible to improve the liver functional lesion in severe craniocerebral injury.