目的:探讨血清门冬氨酸氨基转移酶(AST)、谷氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、总胆红素、白蛋白(ALB)、甲胎蛋白(AFP)等术前血液生化指标对经手术治疗的原发性肝细胞癌(HCC)患者术后生存时间的影响,为HCC患者的手术预后判断提供依据。方法:收集接受手术的原发性HCC患者500例,对其进行随访观察,采用Kaplan-Meier法和Log-rank检验进行生存分析,将生存分析中有意义的因素引入Cox回归模型。结果:AFP、AST、ALP、ALB是影响经手术治疗的HCC患者术后生存时间的独立危险因素[RR(95%CI)分别为1.779(1.330~2.308)、1.391(1.049~1.843)、2.063(1.497~2.844)、0.636(0.493~0.821)]。结论:术前检测AFP、AST、ALP、ALB对原发性HCC患者手术预后判断具有重要价值。
Aim:To investigate the value of aspartate aminotransferase ( AST) , alanine aminotransferase ( ALT) , alka-line phosphatase(ALP), total bilirubin, albumin(ALB), alpha fetoprotein(AFP) and other biochemical indexes of blood in predicting postsurgical survival time of the patients with primary hepatocellular carcinoma ( HCC) , and provide basis for surgeons′clinical treatment .Methods:A total of 500 patients with primary HCC underwent hepatectomy were followed up . Survival analysis was carried out using Kaplan-Meier method and Log-rank test.The multivariate analysis was conducted u-sing Cox proportional hazard model .Results:AFP,AST,ALP,and ALB were independent risk factors for survival time of the patients with primary HCC[RR(95%CI)=1.779(1.330-2.308),1.391(1.049-1.843),2.063(1.497-2.844), and 0.636(0.493-0.821)].Conclusion:AFP,AST,ALP,and ALB could be used as prognostic indexes for patients with primary HCC before operation .