目的探讨精神分裂症患者的注意网络功能和面孔情绪认知功能障碍及两者问的关系。方法采用注意网络测验(ANT)和中国人面孔情绪测验(CFET)对50例未用抗精神病药的精神分裂症患者(患者组)进行评估,并与53名正常健康者(对照组)进行比较。结果(1)ANT:患者组的平均反应时间[(743.0±97.0)ms]长于对照组[(668.9±95.8)ms,P〈0.01],定向网络效率[(30.1±30.7)ms]低于对照组[(49.6±21.3)ms,P〈0.01]。(2)CFET:患者组和对照组的总分[分别为(75.46±13.28)分和(105.64±4.82)分]及对六种基本情绪的认知评分[分别为:喜(18.82±0.52)分和(19.81±0.39)分、怒(15.10±4.63)分和(18.23±1.37)分、悲(12.96±5.11)分和(18.17±1.52)分、惊(13.24±5.03)分和(18.77±1.12)分、怕(5.96±3.99)分和(15.11±2.15)分、厌(9.38±5.47)分和(15.47±2.18)分]差异均有统计学意义(P〈0.01)。(3)Spearman相关分析:患者组ANT正确率与CFET总分呈正相关(r=0.285),ANT平均反应时间与CFET总分(r=-0.302)和对情绪怒的认知评分(r=-0.296)呈负相关,而ANT警觉效率评分与对情绪厌的认知评分(r=0.401)呈正相关(均P〈0.05)。结论精神分裂症患者存在注意定向功能障碍和广泛的情绪认知缺陷,注意功能与情绪认知总体水平存在相关。
Objective To investigate the characteristics of attention network and facial emotion recognition and their association in patients with schizophrenia Methods Fifty naive-medication schizophrenic patients and 53 healthy subjects were tested with the Attention Network Test (ANT) and the Chinese Facial Emotion Test ( CFET). Results Compared with healthy subjects, schizophrenic patients showed significantly decreased orienting efficiency [ (49. 6 ± 21.3 ) ms vs. ( 30. 1 ± 30. 7 ) ms ] and prolonged overall reaction time [ (668.9 ± 95.8 ) ms vs. (743.0 ± 97.0) ms ] of ANT performance, and significantly decreased score (P 〈0. 01) in recognition of the six basic facial emotion of CFET performance. There was significant positive correlation ( P 〈 0. 05 ) between the accuracy of ANT and the total score of CFET, negative correlation ( P 〈 0. 05 ) between the overall reaction time of ANT and the total score or angry subscore of CFET, and a positive correlation (P 〈 0. 05 ) between the alerting subscore of ANT and disgust subscore of CFET in schizophrenic patients. Conclusion The results indicate some specific attention network and general emotion recognition deficits in schizophrenia, and attention may be associated with affect perception.