中文摘要：

目的：探讨不同干预状态下大鼠结肠主要运动模式——长距离收缩（LDC）的特征。方法：取40只雄性SD大鼠随机分为3组,分别给予酵母抽提物（YE）及生理盐水（对照组）急性灌胃3d、神经阻断剂河豚毒素（TTX）和氯贝胆碱（bethanechol）干预、将结肠均分为近远端独立观察,用时空图记录大鼠结肠的基本运动模式LDC的变化。结果：营养物质酵母抽提物（YE）可使LDC收缩时间延长,传播速度减慢;胆碱能M1受体激动剂氯贝胆碱可在神经阻断剂河豚毒素（TTX）作用的情况下使结肠重新出现LDC,但收缩速度同样减慢,变为巨大而缓慢推进的LDC;将结肠头尾端均分开后,尾端结肠仍可独立于近端结肠而出现LDC,其收缩速度明显快于近端结肠,传播时间缩短。结论：营养物质、药物等都可使LDC出现不同的特征性改变,这些运动模式的变化主要体现了结肠的肌源性活性及自主起搏功能,从而对消化吸收产生综合调节作用。

英文摘要：

Objective： To explore the features of long distance contraction（LDC） of rat colon in different conditions. Methods： Forty rats were divided randomly and equally into three groups. Group 1： YE group, giving yeast extraet（YE） and Normal Saline（NS） respectively in 3 consecutive days through garage administration acutely; Group 2： TTX and bethanechol group, after TTX admin istration, adding bethanechol to stimulate myogenic components to generate LDC; Group 3： proximal and distal LDC group, the pan-colon was separated into two parts from the middle. The spatiotemporal map was made by measuring the diameter changes of the colon in the organ bath. Results： YE increased the contraction length of LDC and made the contraction slower; The mus carinie acetylcholine receptor 1 agonist Bethanechol could recover LI）C after the neurotoxin TTX, and make LDC huge and slow-propagating; LDC could also appear independently in the distal co-lon without the proximal colon, and its speed was faster and contraction length shorter compared with LDC in the proximal colon. Conclusion： Nutrients, drugs and so on can change the charac- teristics of LDC, which mainly reflects the myogenic control and pacemaker function of the colon, thus exerts its comprehensive regulating effect to the gastrointestinal tract.