中文摘要：

目的研究焦炉作业工人尿中多环芳烃（PAHs）代谢物与血尿酸水平的关联性，为研究PAHs的致病机制提供新的线索。方法按工作不同岗位将1302名工人分为对照组和低、中、高暴露组，采用高效液相色谱法检测不同工作环境中PAHs浓度；采用问卷调查和健康体检的方式收集工人的职业史和健康状况，同时采集工人的血样及尿样；用日立7020型全自动生化分析仪测定了血尿酸及血肌酐浓度；用气相色谱-质谱联用仪检测尿中10种PAHs代谢物。结果血尿酸水平呈现高暴露〉中暴露〉低暴露〉对照的趋势；1-羟基菲及1-羟基萘四分位与血尿酸水平的关联有统计学意义（P〈0．05）；校正了PAHs代谢物相关关系的影响后，仅1-羟基菲与血尿酸升高的关联有统计学意义（P=0．001）；校正混杂因素后，Logistic回归分析显示，将1-羟基菲四分位后，以第一分位作为参照，第二、三及四分位高尿酸血症的OR值分别为1．55、1．57和2．35。结论焦炉作业工人尿中1-羟基菲与血尿酸水平升高呈剂量一效应关系，且PAHs中菲的暴露可能是工人高尿酸血症的危险因素。

英文摘要：

Objective To analyze the relationship between metabolites of polycyclic aromatic hydrocarbons （PAHs） and serum uric acid levels in coke oven workers and to provide new clues to the pathogenic mechanism of PAHs. Methods A total of 1302 coke oven workers were divided into four groups, namely control group and low-, intermediate-, and high-dose exposure groups. The concentrations of ambient PAHs at each workplace were determined by high-performance liquid chromatography. The detailed information on the occupational history and health of workers was collected by questionnaire survey and physical examination, and so were their blood and urine samples. Serum uric acid and creatinine levels were measured using a Hitachi 7020 automatic biochemical analyzer. Ten urinary PAH metabolites were detected by gas chromatography-mass spectrometry. Results Serum uric acid levels were the highest in the high-dose exposure group, followed by the intermediate- and low-dose exposure groups, and were the lowest in the control group. There were significant correlations between serum uric acid levels and the quartiles of 1-hydroxynathalene and 1-hydroxyphenanthrene （P〈0.05）. After adjustment for PAH metabolite-related relationship, only urinary 1- hydroxyphenanthrene was significantly correlated with serum uric acid levels （P=0.001）. After adjustment for confounding factors and using the 1st quartile of l-hydroxyphenanthrene as a reference, the odds ratio for hyperuricemia in subjects with the 2nd, 3rd, and 4th quartiles of 1-hydroxyphenanthrene were 1.55, 1.57, and 2.35, respectively. Conclusion Urinary 1-hydroxyphenanthrene is associated with a dose-response increase in serum uric acid levels in coke oven workers, and exposure to phenanthrene in PAHs may be a risk factor for hyperuricemia.