中文摘要：

目的探讨中老年女性正常范围内血清γ-谷氨酰转移酶（γ-GT）水平与代谢综合征（MS）的关系。方法选取重庆市南岸区光电路40岁以上女性居民为调查人群，对所有受试者进行问卷调查、体格检查，并采血检测血糖、血脂、肝肾功能等生化指标。最终纳入1308名γ-GT处于正常范围的女性。将研究对象按γ-GT四分位值分组，分析MS的患病率、患病风险及女性绝经状态与γ-GT的关系。结果随着γ-GT水平的升高，研究对象多个代谢指标趋于恶化，绝经人数逐渐增加；γ-GT第1个四分位组至第4个四分位组MS的患病率分别为22．5％、27．4％、42．7％、58．5％（P〈o．01）。γ-GT水平处于第4个四分位数时研究对象的MS、中心性肥胖、高甘油三酯、高血压及高血糖患病风险分别是第1个四分位组的2．92倍、2．3l倍、3．76倍、1．84倍及1．63倍。γ-GT水平随着MS代谢综合征组分个数的增加而显著上升（P〈0．01）。多元逐步回归分析显示，甘油三酯、腰围、绝经状态、餐后2h血糖及体重指数是1．GT水平的独立影响因素。结论中老年女性血清γ-GT是一种与绝经状态独立相关的代谢危险因素；γ-GT处于正常范围时，其水平的升高提示MS的患病风险增大。

英文摘要：

Objective To explore the correlation of serum γ-glutamyltransferase （γ-GT） level in normal range to metabolic syndrome （MS） in middle-aged and elderly Chinese women. Methods Female inhabitants aged 〉40 years in Nan＇an community, Chongqing, were recruited to receive questionnaire interview and physical examination. Blood glucose, lipid, liver and kidney function profiles were also examined. A total of 1308 subjects were involved in our study, and they were divided into four groups according to the γ-GT quartiles. The correlation of MS prevalence, odds ratio and the relation of menopausal status with γ-GT level was analyzed. Results As the quartile of serum γ-GT level increased, the multiple metabolic risk profiles tended to deteriorate, and the number of postmenopausal women increased gradually. From the first quartile to the fourth quartile of γ-GT level, the prevalence of MS was 22.5%, 27.4%, 42.7% and 58.5%, respectively （P〈0.01）. Compared with those subjects in the first quartile of γ-GT, the MS risks in the fourth quartile increased by 2.92-fold, central obesity by 2.31-fold, high triglycerides by 3.76-fold, hypertension by 1.84-fold, and hyperglycemia by 1.63 fold. The γ-GT levels increased significantly in proportion to the number of elements of MS （P〈0.01）. Multiple stepwise regression analysis showed that triglycerides, waist circumference, menopausal status, 2h postprandial blood glucose and body mass index were independent influencing factors of γ-GT levels. Conclusions Serum γ-GT is an independent metabolic risk factor related to woman＇s menopausal status. An increased ＂y -GT level in normal range might imply an increased MS risk in middle-aged and elderly Chinese women.