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中文摘要：
探讨不同糖耐量个体氧化应激与β细胞第一时相分泌功能的关系.比较各组8-羟基脱氧尿苷（8-OHdG）、丙二醛、超氧化物歧化酶（SOD）、脂联素、0～10 min胰岛素曲线下面积（AUC）、急性胰岛素反应（AIR3-5）等指标.发现随病情发展,氧化应激指标水平升高,抗氧化酶活性、脂联素及β细胞第一时相分泌功能下降,丙二醛、8-OHdG与脂联素、稳态模型评估的胰岛β细胞功能指数（HOMA-β）、AUC、AIR3-5负相关,SOD与脂联素、HOMA-β、AUC、AIR3-5正相关,8-OHdG、SOD是AIR3-5的独立相关因素.氧化应激对β细胞第一时相分泌功能有显著影响,可能与2型糖尿病的发病机制密切相关.
英文摘要：
The relationship between oxidative stress and the first-phase of pancreatic β cell insulin secretion in subjects with different statuses of glucose tolerance was explored. Fasting adiponectin, 8-hydroxydeoxyguanosin （ 8-OHdG）, malondialdehyde （ MDA ）, superoxide dismutase （ SOD ）, insulin area under the curve （ AUC ） from 0 to 10 min, and AIR3-5 were measured. The levels of oxidative stress-related markers were elevated, the activities of superoxide dismutase,adiponectin, and first-phase of insulin secretion were reduced with the disease progression. MDA and 8-OHdG were negatively correlated with adiponectin, homeostasis model assessment β cell function index （ HOMA-β ）,AUC ,and AIR3-5. SOD was positively correlated with adiponectin, HOMA-β, AUC, AIR3-5. The plasma 8-OHdG and SOD were independently associated with AIR3-5. Oxidative stress exerts a significant effect on the first phase of pancreatic β cell insulin secretion, which may contribute to the pathogenesis of type 2 diabetes.
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