中文摘要：

通过绘制伪三元相图确定形成o／w型丹皮酚微乳的区域，并通过微乳的体外透皮速率进一步优化丹皮酚微乳的处方，并考察了微乳的外观、形态、粒径分布等性质。结果表明，优选的处方为肉豆蔻酸异丙酯-卵磷脂-烷基多葡萄糖苷-1，2-丙二醇．水（0．58：0.3：0．6：0．45：3），所制微乳澄清透明，平均粒径为（32．5±5．0）nm，12h累积渗透量为1．27×10^3μg／cm^2。

英文摘要：

Pseudo-ternary phase diagrams were drawn to obtain the area of o/w microemulsion formation. The formulation of paeonol microemulsion was further optimized with in vitro permeation of paeonol. The properties including appearance, particle size and distribution were examined. The results showed that the optimized formulation was composed of isopropyl myristate-lecithin-alkylpolyglucosides-propylene glycol-water（0.58 ： 0.3 ： 0.6 ： 0.45 ： 3）. The appearance of the prepared microemulsion was clear with the mean diameter of （32.5±5.0）nm. The 12 h accumulative permeation amount was 1.27×10^3μg/cm2.