中文摘要：

G-protein-coupled 受体家族 ases (GRK ) 与 G-protein-coupled 受体(GPCR ) 的 agonist-activatedform 交往影响受体 phosphorylation 并且开始受体发信号，或不敏感性的深刻缺陷。GPCR 形成房间表面受体的最大的家庭，并且在 GRK 功能背叛处于许多病理学的状况有潜在的后果到刺激 affectGPCR 的生物回答。

英文摘要：

G-protein-coupled receptor kinases （GRKs） interact with the agonist-activated form of G-protein-coupled receptor （GPCR） to affect receptor phosphorylation and to initiate profound impairment of receptor signaling, or desensitization. GPCR forms the largest family of cell surface receptors, and defects in GRK function have the potential consequence to affect GPCR-stimulated biological responses in many pathological situations.