Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice
- ISSN号:1671-4083
- 期刊名称:《中国药理学报:英文版》
- 时间:0
- 分类:Q754[生物学—分子生物学] S859.8[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
- 作者机构:[1]Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China, [2]Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China, [3]Wendeng Zhenggu Hospital of Shandong Province, Wendeng 264400, China, [4]School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, 6009, Western Australia, Australia
- 相关基金:Acknowledgements This work was supported by the grants from the National Nat- ural Science Foundation of China (No 81172549, 81228013 and 81301531), the Shanghai Science and Technology Development Fund (No 11XD1403300 and 12140901300), the Program of Key Disciplines of Shanghai Municipal Education Commission (No J50206), and the Opening Project of Shanghai Key Laboratory of Orthopaedic Implant (KFKT2011003). The authors would like to thank Dr John PRICE for providing the MDA-MB- 231SArfp cell line.
关键词:
人乳腺癌细胞, 荷瘤小鼠, 肿瘤生长, 破骨细胞, 微环境, 白花, 浓度依赖性, 衰减, plumbagin, naphthoquinone, breast cancer, lytic lesion, osteoclast, bone microenvironment, apoptosis, in vivo imaging
中文摘要:
To whom correspondence should be addressed. E-mail ttt@sjtu.edu.cn