中文摘要：

研究由北京大学医学物理和工程北京市重点实验室和北京海思威科技有限公司合作研发的HW-Plan三维放射治疗计划系统在临床使用时的安全性和有效性。HW-PlanV1，0是三维适形放疗软件产品。本论文用HW-PlanV1．0三维放射治疗计划系统和中国医学科学院肿瘤医院的商用放疗计划系统分别对肿瘤部位和种类具有代表性的50个真实病例进行严格的放疗计划，然后对计划的结果进行分析和比较。分析方法包括1值统计方法，比较的内容包括MU值、等中心剂量值、三维剂量分布等。实验结果表明，HW．PlanV1．0能够完成临床肿瘤三维适形放射治疗计划的设计，同目前经过国内外市场准入批准的商用治疗计划系统对相同病例所做的结果在误差允许范围内一致，符合临床使用条件下的安全性和有效性要求。

英文摘要：

To investigate the safety and validity of HW-Plan 3-D TPS V1.0 in clinical cases, we performed the clinical trials of HW-Plan 3D TIPS V1.0 in Tumor Hospital of Chinese Academy of Medical Science. 50 typical cases of tumor patients were treated in the trials using both HW-Plan 3D TPS V1.0 and commercial treatment planning system. The results were analyzed using＇y-evaluation method. The quantities compared between two systems are MU values, dose values at isocenter, 3D dose distribution and etc. Clinical application results indicate that HW-Plan TPS fulfills all the requirements of clinical usage for 3-D conformal radiotherapy. Results of the comparison between HW- Plan TIPS and reference TPS are acceptable. All of the results prove that HW-Plan TIPS is safe and effective for clinical practice.