中文摘要：

为了评估在不同高压、滤光片厚度和管电流条件下的小动物成像，开发了一套动物成像微型CT装置，并在此装置上进行了不同高压、滤光片厚度、球管电流和曝光时间条件下的老鼠成像。以蒙特卡罗软件包PENELOPE为基础，开发了模拟本装置使用的X射线球管光谱的模型。同时，基于Matlab平台开发了计算X射线柬各种参数，包括平均能量、光强变化以及透射率变化等的软件平台。评估了各种影响微型CT成像的参数对信噪比（SDNR）的影响，并分析了成像参数选择与信噪比之间的关系。文中一系列针对小动物成像和图像质量评估的工具和方法可被广泛应用于小动物成像领域。

英文摘要：

To evaluae small animal imaging with individual different high voltage, filter thickness and tube current, an animal X-ray micro-computed tomography （micro-CT） system based on panel detector is developed and a rat is scanned by using the system with individual high voltage, tube current, filter thickness, and exposure time. A model is presented based on the Monte Carlo code PENELOPE for generating the X-ray spectra of X-ray tube used in the micro-CT system. A platform developed based on Matlab allows for calculating beam quality parameters, including the average energy of X-ray beam, the change of transmition rate and the input X-ray fluence. The factors affecting the signal difference to noise ratio （SDNR） of micro-CT are investigated and the relationship between SDNR and scan combinations is analyzed. A series of tools and methods are developed for small animal imaging and imaging performance evaluation in the field of small animal imaging.