中文摘要：

目的探讨糖尿病高血压大鼠肾脏单核细胞趋化蛋白1（MCP-1）表达变化及舒洛地特对MCP-1表达的影响。方法18只Wistar大鼠随机分为3组：对照组（C组）、糖尿病高血压组（D组）、舒洛地特治疗组（s组），每组各6只。采用链脲佐菌素（STZ）＋醋酸脱氧皮质酮（IX）CA）＋盐水建立糖尿病高血压大鼠模型。第8周测定尾动脉压、尿白蛋白。于第8周末处死动物，PAS染色观察肾小球病理改变，免疫组织化学法及逆转录聚合酶链反应（RT-PCR）分别检测MCP-1蛋白及mR—NA表达改变。结果第8周末D组尿白蛋白量及肾组织MCP-1表达显著高于C组（P〈0．05），S组尿白蛋白量及肾组织MCP-1表达较D组降低（P〈0．05）。结论舒洛地特可通过降低。肾组织MCP-1表达，减轻糖尿病高血压大鼠病理损伤。

英文摘要：

Objective To investigate the effects of sulodexide on the expression of monocyte cbemoattractant protein （MCP-1） in streptozotocin （STZ） diabetic desoxycortieosterone acetate （DOCA）-hypertensive rats. Methods Wistar rats were randomly divided into 3 groups： control group （C）, STZ diabetic IX）CA-hypertensive group（D） and sulodexide-treated group（S）. Systolic pressure and urinary albumin for 24 h were measured： Animals were sacrificed at the week 8. Renal morphological changes were examined under the light microscopy. The expression of MCP-1 in kidney was detected by immunohistochemistry and RT-PCR. Results The expression of MCP-1 in kidney was increased remarkably in STZ diabetic DOCA-hypertensive group as compared with control group（P%0. （15）. As compared with STZ diabetic DOCA-hypertens~ve group, the expression of MCP-1 was significantly de- creased in sulodexide-treated group（P〈0. 05）. Conclusions Sulodexide exerted renoproteetive effects i＇n STZ diabetic IX）CA-hypertensive model. The mechanism may be at least partly correlated with the suppression of increasing expression of MCP-1 in kidney.