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蛋白质结晶化原理及技术方法研究进展
  • ISSN号：0253-2395
  • 期刊名称：山西大学学报(自然科学版)
  • 时间：2013.11.15
  • 页码：591-598
  • 分类：O74[理学—晶体学]
  • 作者机构：[1]山西大学物理电子工程学院,山西太原030006, [2]山西大学分子科学研究所,山西太原030006
  • 相关基金：基金项目：国家理科基地建设项目（J1103210）;山西省回国留学人员科研资助项目（2011-017）
  • 相关项目：山西大学物理学基地
作者： 刘小利|薛佳|张东东|张欣宇|
关键词： 生物大分子, 蛋白质, 晶体, X-射线晶体衍射, 结晶化, Bio-macromolecule , protein, crystal, X-ray diffraction, crystallization
中文摘要：

随着人类基因组计划的完成，近年来生物大分子的结构与功能研究成为生命科学关注的热点．晶体学作为结构生物学的基础，培养出高质量的单晶，对于蛋白质、核酸等生物大分子三维空间结构的测定是至关重要的．文章分析和总结了蛋白质结晶的原理、常用的结晶化方法以及促进蛋白质结晶化技术研究的新进展．

英文摘要：

With the completion of the human genome project, the structure and the function of bio-macro- molecules become a hot topic in life science. The crystallography is the basis for structural biology, to get single crystal with good quality remains a major bottleneck for structural determination of bio-macromole cules, such as protein, nucleic acid and their complexes. This paper introduces and analyses the basic theory and method for protein crystallization, as well as the recent progress in protein crystallization.

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山西大学物理学基地
期刊论文 137 会议论文 3
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期刊信息
  • 《山西大学学报：自然科学版》
  • 北大核心期刊（2011版）
  • 主管单位:山西省教育厅
  • 主办单位:山西大学
  • 主编：杨斌盛
  • 地址：太原市坞城路92号
  • 邮编：030006
  • 邮箱：xbbjb@sxu.edu.cn
  • 电话：0351-7010455
  • 国际标准刊号：ISSN：0253-2395
  • 国内统一刊号：ISSN：14-1105/N
  • 邮发代号:22-42
  • 获奖情况:
  • 边疆七年获山西省一级期刊荣誉（1993-1999）
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,英国动物学记录,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）
  • 被引量:5651