中文摘要：

酒精性肝病（alcoholic liver disease,ALD）的发生发展过程与体内多种细胞因子有关,尤其是肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）和转化生长因子-β（transforming growth factor-β,TGF-β）在调节肝细胞的凋亡过程中具有重要作用。TNF-α可引起肝细胞凋亡与炎症反应等,抗TNF-α治疗能明显减轻酒精引起的肝损害;TGF-β具有增加细胞外基质的合成和抑制细胞外基质降解的作用,TGF-β1升高与肝纤维化密切相关。细胞因子可能是防治酒精性肝病的有效分子靶点。

英文摘要：

Cytokines,especially tumor necrosis factor-a（TNF-a） and transforming growth factor-b（TGF-b）,play an important role in the mechanisms in the pathogenesis of alcoholic liver disease（ALD）,such as steatohepatitis,fibrosis,and cirrhosis.TNF-a and TGF-b are involved in the apoptotic liver cell death.TNF-a also takes part in the inflammation related to ALD.TNF-a antibody can distinctly alleviate alcohol-induced liver injury.TGF-b can increase extracellular matrix synthesis and inhibit its degradation;TGF-b1 is intimately related to the alcoholic liver fibrosis.Cytokines are promising targets for preventing and treatment of the ALD.