中文摘要：

目的：分析糖尿病肾病（DN）中医证候分布规律及其与实验室指标的典型相关性,探讨中医证候与DN危险因素的内在联系。方法：采用多中心流行病学调查的方法,收集符合纳入标准的DNⅢ期、Ⅳ期和Ⅴ期患者共350例,分析DN各期患者中医证候学和实验室指标的异同,对证候积分与15项常用实验室指标进行典型相关分析。结果：①证候学分析：DNⅢ期本虚证以气虚、阴虚为主,Ⅳ期以阴虚、阳虚为主,Ⅴ期以阴虚、阳虚和血虚为主。各期标实证均以血瘀证为主。②证候与实验室指标的典型相关分析：血肌酐与阳虚证、餐后血糖与阴虚证、低密度脂蛋白胆固醇与湿热证具有典型相关关系。结论：DN中医证候演变是从气阴两虚到阴阳两虚最终发展到气血阴阳俱虚的过程,血瘀证贯穿疾病始终。实验室指标与证候积分的典型相关分析为中医药防治DN提供了依据,也为开展中医药多中心临床研究奠定了客观评价基础。

英文摘要：

Objective：To investigate the distribution pattern of TCM syndrome of diabetic nephropathy（DN） patients,and their relationship with main risk factors of DN.Methods：Multi-centric epidemiological field survey was adopted to collect the main clinical data of 350 DN patients fit to the inclusive/exclusive criteria.The TCM syndrome and laboratory parameters were compared based on different stages.The canonical correlation relationship between TCM syndrome score and fifteen commonly used laboratory parameters were analyzed.Results：① Distribution pattern of TCM syndrome：the main def iciency syndromes of DN stage Ⅲ were yin and qi deficiency;the main deficiency syndrome of DN stage Ⅳ were yin and yang deficiency,and stage Ⅴ were yin,yang and blood deficiency,while blood stasis was the main excess syndrome of DN.② The results of canonical correlation analysis revealed that there were canonical correlation between serum creatinine and yang deficiency syndrome,postprandial blood glucose and yin deficiency syndrome,low density lipoprotein and damp-heat.Conclusion：The developmental process of TCM syndrome of diabetic nephropathy was qi and yin deficiency firstly,and then yin and yang deficiency and finally to universal deficiency of qi,blood,yin and yang.Blood stasis was the most important excess syndrome.The canonical correlation between TCM syndrome score and laboratory parameters may provide evidence for treating and preventing DN by TCM means.