中文摘要：

锰主要以Mn^2＋形式存在,有人发现其具有与其他过渡性金属离子截然相反的抗氧化活性,采用自旋捕捉-ESR技术、芳环羟基化反应-高效液相色谱（HPLC）法和琼脂糖电泳法三种方法研究Mn^2＋参与类Fenton反应的情况时,均检测到Mn^2＋与H2O2反应产生.OH,Mn^2＋与H2O2反应可以发生类Fenton反应,产生.OH。这一现象的产生可能是Mn^2＋引起生物体内氧化损伤之故。同时显示,Mn^2＋的类Fenton反应是否产生.OH与反应过程Mn^2＋以及其他成分浓度有关（如高浓度抑制,低浓度促进）,为诸多文献中Mn^2＋作为促氧化剂还是抗氧化剂的争论提供了可能解释。同时Mn^2＋能引起.OH持续低量的产生为一些慢性疾病的发生提供了合理的解释。

英文摘要：

Mn （ H ） is the mostly form of manganous. Unlike the other transition metal - ions, it has antioxidative charater. ESR spectroscopy, HPLC with fluorescence detection and agarase gel electrophoresis were used to detect the phenomenon when maganous participated in Fenton like reaction. The result showed that manganous could substitute for iron or copper ion in Fenton system to evolve hydroxyl radical. It was suggested that hydroxyl radical initiated by manganous complex and hydrogen peroxide might be an important reason why manganous could induce oxidative stress in vivo. Simuhaneouslu, the production of ·OH related to the concentration of manganous and the other component. The result indicated that manganous inhibited the productioj of·OH when the ionic concentration was higher, but accelerate obviously when it was lower. This research has provided experiment and theoretical basic about the dispute whether manganous inhibit or accelerate the production of·OH.