以3,4-二氯苯甲醛、对羟基苯甲醛,吡咯和1,5-二溴戊烷(或1,6-二溴己烷)为原料,经两步反应合成了溴烷氧基氯苯基卟啉(2a或2b);2与5-氟尿嘧啶反应,合成了两种新型的氯代苯基卟啉-5-氟尿嘧啶[1a(产率28.26%)和1b(产率29.34%)],其结构经UV-Vis,1HNMR,IR和MS表征。
Bromine-alkoxy-chlorophenyl porphyrin(2a or 2b) were synthesized by a two-step reaction from 3,4-dichlorobenzaldehyde, p-hydroxybenzaldehyde, pyrrole and 1,5-dibromopentane( or 1,6-di- bromohexane). Two new chlorophenyl porphyrin-5-fluorouracils were synthesized by the reaction of 2 with 5-fluorouracil. The yields reached 28.26% and 29.34%, respectively. Their structures were characterized by UV-Vis, 1H NMR, IR and MS.