中文摘要：

药理活性研究表明,毛冬青总皂苷不仅具有明显降低血浆粘度的作用,而且还能明显抑制兔离体动脉条的收缩。继续对其总皂苷的化学成分进行研究,从其正丁醇萃取部位分离得到5个三萜皂苷类化合物,经理化性质及波谱方法鉴定为：mussaendoside R（1）、ziyu-glycoside I（2）、Lucyoside H（3）、ilexoside A（4）、il-exoside O（5）。其中1、2、3为首次从该植物中分离得到。

英文摘要：

Traditional chinese medicine of Ilex pubescens（Mao-Dong-Qing） is commonly used to treat the cardiovascular diseases in South China.The preliminary bioassays showed that the total saponins isolated from Ilex pubescens exhibited significant potent degrading the plasma viscosity in rats.Meanwhile,our recent works indicated that the n-BuOH soluble fractions of ethanol extract（70%） from the root of the same species obviously inhibited the contraction（60 μg/mL） of rabbit thoracic aorta induced by norpinephrine in vitro.As a continuation of bioactive constituent from the n-BuOH of Ilex pubescens,five triterpene saponins were isolated.Their structures were elucidated by chemical,physical methods and spectroscopic analysis methods.As a result,they were identified as mussaendoside R（1）,ziyu-glycoide I（2）,Lucyoside H（3）,ilexoside A（4）,ilexoside O（5）,excepescially.Compounds 1,2 and 3 were firstly obtained from Ilex pubescens.