中文摘要：

库普弗细胞（KCs）即肝固有巨噬细胞，是门脉系统的第一道屏障，它也是肝内主要的炎症递质细胞，参与多种肝脏疾病的发生、发展。随着生活习惯及饮食结构的改变，非酒精性脂肪肝（NAFLD）的发病率逐年升高，但其发病机制尚未完全明确，治疗上也缺乏有效措施。近年来众多研究显示库普弗细胞与该病的发病过程密切相关。本文就近年来库普弗细胞功能研究与NAFLD发病机制的关系进展作一概述。

英文摘要：

Kupffer cells, liver-resident macrophages, serve as the first protective barrier in liver and are also respon- sible for the release of inflammatory mediators contributing to the development of various liver disorders. With the altera- tion of human＇ s living habits and dietary structure, the increasing prevalence of non-alcoholic fatty liver disease （NAFLD） is gaining its worldwide concern. However, the pathogenesis of NAFLD and the corresponding treatment need further explorations. In recent years, accumulating evidence suggests that kupffer cells play crucial roles in NAFLD. This review summarizes the resent research progresses that have been made on the involvement of KCs in NAFLD.