中文摘要：

目的：探讨针刺延缓衰老的机制。方法：采用快速老化小鼠（SAMP10）、正常老化小鼠（SAMR1）为模型，运用地高辛标记的非放射性Northern blot技术，观察8月龄SAMR1对照组、SAMP10对照组、SAMP10针刺组及SAMP10非穴位刺激组全脑、皮层和海马NF-E2、YB-1、LRG47基因表达的变化。结果：SAMP10对照组小鼠NF-E2、YB-1、LRG47在全脑、皮层、海马中的表达下调，针刺后表达上调并趋向于正常组。结论：SAMP10小鼠脑衰老与NF-E2、YB-1、LRG47基因表达异常有关，针刺可以通过调节NF-E2、YB-1、LRG47基因表达增强红细胞系统功能和细胞增殖，提高细胞抗菌免疫，从而起到延缓衰老的作用。

英文摘要：

Objective To explore the mechanism of acupuncture in delaying aging. Methods Using SAMP10 mice and normal control SAMR1 as model and applying RT-PCR and DIG probed Northern blot techniques to observe expression of NF-E2, YB-1, LRG47 genes in whole brain, cortex and hippocampus in the 8-month SAMR1 control group, 8-month SAMP10 control group, 8-month SAMP10 acupuncture group and 8-month SAMP10 nonpoint acupuncture group. Results In the SAMP10 control group, the expression of NF-E2, YB-1 and LRG47 were down-regulated in the whole brain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal. Conclusion Aging of the SAMP10 mouse brain is related with expression of NF-E2, YB-1 and LRG47 genes, and acupuncture can regulate the expression of NF-E2, YB-1 and LRG47 genes, improving the functions of erythrocyte series, increasing proliferation of cells and immune function of cells in anti-bacteria, hence antiaging.