过氧化物酶体增殖物激活受体(PPAR)属于核受体超家族,分三个亚型,即PPARα、PPARβ/δ和PPARγ。PPARα调节脂质新陈代谢、氧化和脂肪酸的运输及葡萄糖动态平衡并发挥一定的抗炎效应;PPARβ/δ是动脉粥样硬化、脂质、葡萄糖和能量动态平衡的重要调节因子;PPARγ具有抗炎性反应和抗动脉粥样硬化作用。PPAR家族具有多种生物学功能,其与炎症性疾病的关系是目前研究的热点。
Peroxisome proliferator activated receptor (PPAR) belongs to the nuclear receptor superfamily. There are three subtypes: PPARα, PPARβ/δ and PPARγ. PPARα regulates lipid metabolism and transport, fatty acid oxidation, and glucose homeostasis. In addition, PPARα exerts anti-inflammatory effects. PPARβ/δ is an important regulator of atherosclerosis, lipid, glucose, and energy homeostasis. PPARy agonists consistently repress inflammation and reduce atherosclerosis. The biological functions of PPAR and the relationship between PPAR and inflammatory diseases are the focus of researches at present.