中文摘要：

目的：研究两组异构体（R，R）-XY-1到（R，R）-XY-12以及（S，S）-XY-1到（S，S）-XY-12对兔眼血流的影响。 方法：用彩色微球技术测量兔眼在高眼压下（40mmHg）各组织的血流情况。 结果：12个（R，R）-XY化合物以10g／L，50μL的剂量滴入兔眼，其中4个化合物可提高脉络膜血流。所有（S，S）-XY系列的化合物对兔眼血流没有影响。 结论：（R，R）-XY系列中一些化合物可以增加兔眼血流，这些可能对眼部血流降低相关疾病的防治有作用。在24个化合物中，（R，R）-XY-1和（R，R）-XY-9最有药效。

英文摘要：

AIM： To evaluate the effects of two series of enantiomers [ （R, R）-XY-1 through （R, R）-XY-12 and （S, S）-XY-1 through （S, S）-XY-12] on ocular blood flow in rabbits. METHODS： Colored microsphere technique was used for in vivo experiments to determine the ocular blood flow in various tissues of ocular hypertensive （40mmHg） rabbit eyes. RESULTS： Of the twelve compounds of （R, R）-XY series examined, four increased choroidal blood flow at 10g/L, 50μL instilled into eyes. All compounds of （S, S）- XY series were not effective on ocular blood flow. CONCLUSION： Some compounds of （R, R）-XY series increased the ocular blood flow, which might be useful for the prevention and treatment of ocular blood flow related eye diseases. Among all twenty-four compounds, （R, R）-XY-1 and （R, R）-XY-9 seem to be the most potent ones.