中文摘要：

目的：研究ZX-5对缺血后视网膜功能的恢复作用,并比较其光学异构体（R,R）-ZX-5和（S,S）-ZX-5对脉络膜血流及缺血后视网膜功能恢复的影响。方法：用彩色微球技术研究兔高眼压下（40mmHg）脉络膜血流的变化。用视网膜电生理仪测量b波,评价大鼠缺血后视网膜功能的恢复情况。结果：10g/L（R,R）-ZX-5滴眼液50μL能在不同时间点提高脉络膜血流（P〈0.05）,而（S,S）-ZX-5在相同条件下对提高脉络膜血流没有影响。ZX-5和（R,R）-ZX-5在不同时间点对视网膜缺血后功能恢复作用明显（P〈0.05）,（R,R）-ZX-5的作用优于ZX-5;而（S,S）-ZX-5对缺血后视网膜功能的恢复作用不明显。结论：ZX-5和（R,R）-ZX-5对增加脉络膜血流量和促进视网膜功能的恢复有显著功效,（R,R）-ZX-5恢复视网膜功能的作用更强,有可能进一步开发成有效防治眼血流障碍相关性眼病的药物。

英文摘要：

AIM：The effects of ZX-5,as nitric oxide（NO） donor,on ocular blood flow has been investigated using colored microsphere technique in previous study.The relationship between the production of NO by ZX-5 and ocular blood flow has been evaluated.ZX-5 has been shown to have strong positive effect on increasing choroidal blood flow.However,the effect of ZX-5 on retinal function recovery,the effects of its optical isomers,（R,R） -ZX-5 and（S,S） -ZX-5,on choroidal blood flow and retinal function recovery have not been studied and merit investigation.METHODS：Colored microsphere technique was used for in vivo experiments to determine choroidal blood flow of ocular hypertension（40mmHg） in rabbit eyes.Electroretinography was used to measure the b-wave recovery as an indication of retinal function recovery.RESULTS：（R,R） -ZX-5 increased choroidal blood flow at 10g/L,50μL instillation into eyes at all time points（P 〈0.05） .（S,S） -ZX-5 was not effective in increasing choroidal blood flow.ZX-5 and（R,R） -ZX-5 showed significant effects in retinal function recovery after ischemia of the retina at all time points（P 〈0.05） ;whereas（S,S） -ZX-5 did not show significant effect on recovery of b-wave after ischemia at most time points except at 120 and 240 minutes.CONCLUSION：ZX-5 and（R,R） -ZX-5 have high potency in increasing the choroidal blood flow and improving the retinal function recovery.It is hoped that they could be used for the prevention/treatment of ocular blood flow related eye diseases.