中文摘要：

C-met属于酪氨酸激酶受体（receptor tyrosinekinases,RTKs）超家族成员,当与其配体肝细胞生长因子结合后可以引起细胞不同信号通路的改变。微小RNA（microRNA,miRNA）是一类高度保守、内源性、非编码的单链小分子RNA,其长度约为19~25个核苷酸,通过影响靶mRNA的稳定性或抑制其翻译从而对基因进行转录后表达的调控,其在生物的多种生物学过程中发挥着重要作用。研究表明,miRNAs可以通过调控cmet的表达,抑制肿瘤细胞增殖、迁移和侵袭。现就miRNA对肿瘤相关基因c-met调控的研究进展进行综述。

英文摘要：

C-met is the member of the tyrosine kinase receptor （receptor tyrosinekinases,RTKs） family.It can change different signal pathways in cell after combination with its ligand hepatocyte growth factor （HGF）.The microRNA （miRNA） is a kind of highly conservative,endogenous,non-coding single small RNA whose length is about 19-25 nucleotides.It regulates gene expression after transcription by affecting the stability of the target mRNA or inhibit its translation.It plays an important role in many biological processes in the biological process.Studies have shown that miRNAs can regulate the expression of c-met,inhibit tumor cell proliferation,migration and invasion.Regarding the miRNA related to tumor gene c-met regulation research progress are summarized.