中文摘要：

沉默信息调节因子1（silent information regulator 1，SIRT1）是NAD＋依赖的Ⅲ类组蛋白去乙酰化酶，是衰老相关信号通路中的重要分子，参与细胞衰老过程。微小RNA（microRNA，miRNA）是一类长度约为22nt的内源性非编码小分子RNA，通过影响靶mRNA的稳定性或抑制其翻译从而对基因进行转录后表达的调控。研究表明，miRNAs可以通过调控SIRT1的表达，促进细胞衰老。现就miRNA对衰老相关分子SIRT1的调控作用进行概述。

英文摘要：

SIRT1 is a class III histone NAD＋ dependent deacetylase, which is an important molecule in aging- related signaling pathway, and plays a pivotal role in the cell aging process. MicroRNAs （miRNAs） are endogenous, -22 nucleotides, small non-coding RNAs which typically regulate gene expression after transcription by affecting the stability or translation of targeted mRNA. Studies have shown that miRNAs can promote cellular senescence by regulating the expression of SIRT1. This review describes the potential functions of miRNAs in the regulation of SIRT1.