目的:研究中药二黄散对伴有持续性HPV感染的宫颈上皮内瘤变(CIN)Ⅰ患者的治疗效果。方法:选取伴有持续性HPV感染的CINⅠ患者100例,将其随机分为二黄治疗组(50例)和对照组(不作任何治疗,50例)。观察不同时间宫颈病变及HPV转归情况,并结合临床资料进行分析。结果:CINⅠ治疗结束后3、6、9个月不同时间转归率分别为75.0%、81.3%、85.4%,HPV治疗结束后不同时间转归率分别为47.9%、52.0%、60.4%,治疗组CINⅠ及HPV不同时间转归率明显高于与对照组,比较差异均有统计学意义(P〈0.05,P〈0.01)。结论:中药二黄散对伴有HPV感染的CINⅠ患者有较好的治疗作用。
Objective:To investigate the effect of Erhuang Powder on cervical microenvironment of CIN I with human papillo-mavirurus (HPV) infection. Methods:A total of 100 cases with CIN Ⅰ with HPV persistent infection were entered in the random-ized group study:Erhuang Powder group and observation group ( no any therapy, control group ). Each group included 50 cases. The treatment outcome was evaluated. Results:The total effective rates of CIN I with HPV were 85.4%, 60.4% and 40.0%, 20. 0% in 3,6 and 9 month,which were that higher than those in control group with significant difference(P 〈0.05 ,P 〈0. 01 ). Conclusion:Erhuang Powder can be used for treatment of CIN I wtih HPV infection effectively.