中文摘要：

目的：研究二黄散对伴有HPV感染的CINⅠ患者对宫颈局部免疫状态的影响及治疗效果。方法：选取伴有HPV感染的CINⅠ患者100例,将其随机分为二黄散治疗组（50例,每次用药量为3.8g）和对照组1（不作任何治疗,50例）,同期50例正常妇女为对照组2。观察不同时间宫颈病变及HPV转归情况,并应用酶联免疫吸附试验测定不同时间的阴道灌洗液辅助性T淋巴细胞（Th细胞）1、2细胞因子水平,其中Thl细胞因子以白细胞介素（IL）2、IFN-γ表示,Th2细胞因子以IL-4、10表示,并结合临床资料进行分析。结果：治疗组CINⅠ及HPV不同时间转归率明显高于与对照组1（P〈0.05,P〈0.01）,治疗组患者治疗后IL-2水平均有不同程度升高,与治疗前及对照组1比较,差异均无统计学意义;治疗组患者治疗后IL-4、IL-10水平均无明显变化,与治疗前及对照组1比较,差异也均无统计学意义。治疗组患者治疗后IFN-γ水平均明显升高,与治疗前及对照组1比较,差异有统计学意义。结论：中药二黄散对伴有HPV感染的CINⅠ患者有较好的治疗作用,其治疗机制可能为：通过调节Th1/Th2的免疫平衡清除HPV病毒,且通过调节Th1细胞因子IFN-γ在宫颈病变发展过程中的作用较IL-2可能更为重要。

英文摘要：

Objective：To investigate the improvement of cervical microenvironment and curative of Erhuansan therapy on CINⅠaccompanied by human papillomavirurus（HPV） infection.Methods： A total of 100 cases with CINⅠaccompanied by HPV infection were entered in the randomized group study,Erhuansan therapy group and observed group（no any therapy,control group 1）.healthy women as control group 2.Each group included 50 cases.Evaluate the outcome of them.Vaginal lavage was collected from healthy women and patients of two groups.The level of intedeukin（IL） 2,4,10 and 、interferon-γ（IFN-γ） were detected by enzyme linked immunosorbent assay（ELISA）.Results： The total effective rate of CINⅠand HPV were 85.4%,60.4% and 40.0%,20.0%,at 3 m,6 m and 9 m in therapy group that higher than those in control group with significant difference（P 0.05,P 0.01）.The level of IL-2,IL-4、IL-10 between post-treatment,pre-treatment and control group1 had no significant difference（P 0.05）.the IFN-γlevel of patients after therapy were significantly higher than that of pre-treatment and control group1（P 0.05）.Conclusions： Erhuansan can be used for treatment of CINⅠaccompanied by HPV infection effectively.It may regulate Th1/Th2 immune balance to clean up HPV.IFN-γplays an important role in the defence of cervical epithelial cell.Th1 may be more important than Th2 in lower genital tract infections.