中文摘要：

目的：了解米诺环素联合烟酰胺治疗大疱性类天疱疮的疗效。方法：121例大疱性类天疱疮患者初诊时给予米诺环素200mg／d；烟酰胺600～1500mg／a，服用2周。2周后复查，根据病情或继续口服米诺环素及烟酰胺；或米诺环素及烟酰胺加服少量泼尼松；或停服米诺环素及烟酰胺，改为单独服用泼尼松或用其他方法治疗，总共随访观察24周。结果：使用米诺环素联合烟酰胺治疗2周后达到完全控制40例（33．1％），基本控制48例（39．7％），无效33例（27-3％）。有效者合计88例（72．7％），最终完成24周米诺环素联合烟酰胺治疗的有29例（24．0％）。严重程度与2周后疗效，经Spearman相关分析，r=0．264，P=0．003，有显著相关性。结论：轻中度的大疱性类天疱疮患者，可以考虑首选米诺环素联合烟酰胺治疗。

英文摘要：

Objective： To summarize clinical data of 121 patients with bullous pemphigoid treated with minocycline and nicotinamide in the last ten years. Methods： All newly diagnosed bullous pemphigoid patients were given minocycline 200 mg/d and nicotinamide 600~1 500 mg/d in the first 2 weeks. Afterward, according to the disease status and patients＇condition, patients were given the combination of minocycline and nicotinamide with/without a low dosage of prednisone, or prednisone alone or other treatments. Patients were followed up for 24 weeks. Results： After 2-week treatment, 40 cases （33.1%） achieved fully control while 48 cases （39.7%） achieved partial control. Total 88 cases （72.7%） showed effectiveness and 33 cases （27.3%） showed no response. 29 cases （24.0%） completed the 24-week minocycline combined with nicotinamide therapy. Spearman correlation analysis showed a significant correlation between severity and efficacy after the 2-week treatment（r=0.264, P=0.003）. Conclusions： Minocychne combined with nicotinamide could be considered as the first choice for the treatment of patients with mild and moderate bullous pemphigoid.