中文摘要：

目的：总结寻常型天疱疮（PV）的糖皮质激素（以下简称激素）系统治疗方案。方法：回顾性分析该科治愈并随访至少2年的PV患者。结果：128例患者经激素系统治疗后获得临床治愈（泼尼松或等效激素剂量≤10mg／d或完全停药．且皮损完全消退持续≥6个月），激素平均控制剂量在轻度、中度、重度、严重度患者中分别为（38．9±18．1）mg／d、（51．3±16．2）mg／d、（68．8±15．6）mg／d和（88．3±16．0）mg／d（P〈0．001）。激素控制剂量在≤40mg／d、45～60mg／d、65～80mg／d和〉80mg／d范围时，首次减量时间分别为（85．0±85．9）d、（47．7±36．0）d、（36．3±16．0）d和（27．0±18．1）d（P〈0．001）。全部患者在应用激素6年内达到临床治愈，其中80．2％（101／126）用时≤3年，98．4％（124／126）≤5年。每年激素减量为前一年的50％。结论：PV可在3-6年内临床治愈；按每年50％的速度递减激素可有效控制病情：减量过快或幅度过大是病情复发的主要原因。

英文摘要：

Objective： To summarize the regimen for treating pemphigus vulgaris（PV） with systemic glucocorticoids. Methods： We retrospectively analyzed PV patients who were cured and followed up for at least 2 years in our department from January 2001 to December 2010. Results： 128 cases were completely cured by systemic glueoeorticoids （maintained by prednisone or the equivalent ≤ 10 mg/d, or no medication; lesion free for ≥6 months）. The maintenance dose of daily glucocorticoid for mild, moderate, severe and very severe patients were （38.9±18.1） mg, （51.3±16.2） mg, （68.8±15.6） mg and （88.3±16.0） rag, respectively （P〈0.001）. When the maintenance dose of daily glueocorticoid were ≤40 mg, 45-60 mg, 65-80 mg and 〉80 rag, the respective treatment time were （85.0±85.9） d, （47.7±36.0） d, （36.3±16.0） d and （27.0±18.1） d（P〈0.001） before the reduction of dose. All patients reached clinical cure within 6 years. 80.2%（101/126） of patients were cured within 3 years, and 98.4%（124/126） within 5 years. The dose was annually reduced by 50% of the prior year. Conclusions： PV can be cured within 3-6 years, and effectively controlled by annual reduction of 50% of glucocorticoids. Too much and too fast reduction of glucocorticoids are the major causes of PV relapse.