Di-n-butyltin 氧化物与p-反应了[ N ,N二度( 2-chloroethyl )氨基]产出混合物的安息香的酸{{4-[( ClCH2CH2 ) 2N ] C6H4COOSnBu2 } 2O } 2 ( 1 )并且{4-[( ClCH2CH2 ) 2N ] C6H4COO } 2SnBu2 ( 2 ),它被红外和 1H NMR 系列描绘了。1 的 X 光检查 diffractional 研究揭示是的分子的结构一更暗淡,在哪个二个 Bu2Sn 组经由二被连接衔接氧原子形成一个中央 Bu4Sn2O2 单位。并且锡原子从酸和衔接的氧从二个 n 丁基组和三个氧原子采用二碳。在 vitro,测试显示了化合物 1 对 P388 和 HL-60 房间线展出高 cytotoxicity。
Di-n-butyltin oxide reacted with p-[N,N-bis(2-chloroethyl)amino]benzoic acid to yield the compounds {{4-[(ClCH2CH2)2N]C6H4COOSnBu2}2O}2 (1) and {4-[(ClCH2CH2)2N]C6H4COO}2SnBu2 (2), which have been characterized by IR and ^1H NMR spectra. The X-ray diffractional studies of 1 reveal the structure of the molecule to be a dimer, in which the two Bu2Sn groups were linked via two bridging oxygen atoms to form a central Bu4Sn2O2 unit. And the tin atom adopts two carbons from two n-butyl groups and three oxygen atoms from the acid and the bridging oxygen. In vitro test showed compound 1 to exhibit high cytotoxicity against P388 and HL-60 cell lines.