中文摘要：

瞄准：为了阐明，在在肝损害的恢复过程期间的 non-parenchymal 房间，细胞外的矩阵和卵形的房间之间的相互作用由部分 hepatectomy (PH ) 导致了。方法：我们用组织化学的免疫和两倍免疫检验了卵形的房间， non-parenchymal 房间，和细胞外的矩阵部件的本地化荧光灯的分析在在 N-2-acetylaminofluorene (2-AAF )/PH 老鼠的卵形的房间的增长和区别期间当模特儿。结果：在白天 2 在 PH 以后，小卵形的房间开始在门区域附近增殖了。大多数星形的房间和 laminin 沿着在仙子门区域的肝的窦状隙是在场的。Kupffer 房间和 fibronectin 显著地在整个肝的腹片增加了。从白天 4 ～ 9，卵形的房间进一步传播了进肝的实质，仔细与星形的房间， fibronectin 和 laminin 联系了。Kupffer 房间在白天与卵形的房间混合了 6 然后在仙子门地区减少了。从白天 12 ～ 15，在小 hepatocyte 结节附近定位的肝的星形的房间(HSC ) 的大多数， laminin 和 fibronectin，和他们中的少数出现在结节。Kupffer 房间主要在仙子被限制中央窦状隙。在白天 18 以后，正常的肝腹片结构开始恢复了。结论：本地肝的微型环境可以通过房间房间和房间矩阵相互作用参予卵形的调停房间的肝新生。

英文摘要：

AIM： To elucidate the interaction between non- parenchymal cells, extracellular matrix and oval cells during the restituting process of liver injury induced by partial hepatectomy （PH）. METHODS： We examined the localization of oval cells, non-parenchymal cells, and the extracellular matrix components using immunohistochemical and double immunofluorescent analysis during the proliferation and differentiation of oval cells in N-2- acetylaminofluorene （2-AAF）/PH rat model. RESULTS： By day 2 after PH, small oval cells began to proliferate around the portal area. Most of stellate cells and laminin were present along the hepatic sinusoids in the periportal area. Kupffer cells and fibronectin markedly increased in the whole hepatic Iobule. From day 4 to 9, oval cells spread further into hepatic parenchyma, closely associated with stellate cells, fibronectin and laminin. Kupffer cells admixed with oval cells by day 6 and then decreased in the periportal zone. From day 12 to 15, most of hepatic stellate cells （HSCs）, laminin and fibronectin located around the small hepatocyte nodus, and minority of them appeared in the nodus. Kupffer cells were mainly limited in the pericentral sinusoids. After day 18, the normal liver Iobule structures began to recover.CONCLUSION： Local hepatic microenvironment may participate in the oval cell-mediated liver regeneration through the cell-cell and cell-matrix interactions.