中文摘要：

非酒精性脂肪肝病（non-alcoholic fatty liver disease,NAFLD）在肝脏疾病谱中占据日益重要的地位,其与胰岛素抵抗和氧化应激密切相关。饥饿素（ghrelin）作为一种新发现的从胃内提取的激素,是第一种生长激素促分泌素的内源性配体,能促进生长激素分泌,同时增强食欲,减少脂肪利用,维持能量正平衡,并在改善胰岛素抵抗、抑制炎性反应、抗纤维化和肿瘤等方面有一定作用,可能对NAFLD起到治疗作用。本文就目前国内外关于饥饿素在NAFLD中的研究作一综述。

英文摘要：

Non-alcoholic fatty liver disease （NAFLD） has been playing an increasingly important role in liver disease which is closely related to insulin resistance and oxidative stress.As a newly found hormone purified from stomach,ghrelin is the first endogenous ligand for the growth hormone secretagogue receptor.It can promote the secretion of growth hormone,enhance appetitie,suppress lipometabolism and maintain energy balance,which also cintribute to improvement of insulin resistance,suppression of inflammation reaction,limitation of the development of fibrosis and tumor,etc.Ghrelin probably stands a chance of becoming a new drug treating NAFLD.This review outlines the recent studies on NAFLD and ghrelin both nationally and internationally.