中文摘要：

藁本内酯是川芎和当归的主要有效成分，其化学结构的不稳定性限制了它的进一步研究和临床应用。本实验通过色谱方法对其室温静置一个月后的产物进行制备，得到了14个藁本内酯的转化产物，并通过ESI．MS、NMR等光谱分析法确定了其结构，包括一个新化合物7＇-carboxyl-walllchilide（1）。利用LC．MS峰面积归一化法，确定了藁本内酯及其转化产物的相对含量，阐明了藁本内酯的主要转化产物为其二聚体。

英文摘要：

Ligustilide is one of main active components from Rhlzoma Chuanxiong and Radix Angelicae Sinensis. Howev- er,the instability of ligustilide limits its further research and application in clinics. In this study,the transformation prod- ucm of ligusfillde were prepared,after one month at room temperature,by conventional chromatography and spectroscopic methods. Fourteen transformation products were obtained and elucidated, which included a new dimerphthalide,namely, 7＇-carboxyl-wallichilide （ 1 ）. The relative contents of ligustilide and its fourteen transformation products were determined by area normalization using LC-MS. The results showed that ligustilide dimers were the main transformation products of ligustilide.